Platelet Membrane GPIIb-IIIa Complex

Human platelet membrane glycoprotein IIb/IIIa (GP IIb/IIIa)

The mAb is reactive to platelet coated ELISA plate.

Human, others not tested

Human platelet membrane glycoprotein Glycoprotein IIb/IIIa (GP IIb/IIIa) is a dominate receptor on the platelet membrane with very high molecular weight (>200kDa). After the platelet is activated, the GP IIb/IIIa receptor complex changes conformation and binds to fibrinogen in blood circulation with high affinity. The activation of platelets is initiated locally when the endothelial layer is wounded and the platelets are exposed to the collagen underneath the endothelium. The fibrinogen aggregates with platelets when binding to the GP IIb/IIIa receptor on platelets, thus primary haemostasis (Platelet clot) is formed.

Double distillated water is recommended to adjust the final concentration to 1.00mg/mL.

Hematology, blood coagulation