Staphylococcal Enterotoxin B

Mouse monoclonal antibody to staphylococcal enterotoxin B (SEB)

SEB purified from Staphylococcus aureus

Staphylococcal enterotoxin B

Staphylococcal enterotoxin B (SEB) is an enterotoxin secreted by Staphylococcus aureus. The bacterium thrives on meet, baking and dairy products and also colonizes in host nasal passageway. Ingestion of SEB contaminated food is the common cause of "food poisoning", manifested by flu-like symptoms, vomiting, diarrhea and intestinal cramps. In severe cases, SEB can cause respiratory failure and systemic toxic shock. These symptoms are the results of increased membrane permeability and abnormal activation of T-lymphocytes by SEB. SEB acts as a superantigen by binding directly to major histocompatibility complex class II (MHCII) on antigen presenting cells, thus, causing massive CD4 and CD8 T-cells activation and cytokine production. If unchecked, the process can result in systemic organ failure and death.

Double distillated water is recommended to adjust the final concentration to 1.00mg/mL.

Toxicology, food safety and microbiology