Alpha 1-Antitrypsin

Human alpha1-antitrypsin

This monoclonal antibody reacts with human alpha1-antitrypsin

Human

alpha1-antitrypsin is a protective protease inhibitor. It inhibits elastase released by neutrolphils during inflammatory reaction and irreversibly inactivates trypsin secreted in duodenum and else where. alpha1-antitrypsin normally presents in plasma at 1.5-3.5 mg/mL, but increases in acute phase reaction, malignancies, pregnancy and trauma. Severe hereditary alpha1-antitrypsin deficiency can result in damages to alveoli, chronic obstructive pulmonary disease (COPD), and liver diseases such as jaundice and cirrhosis. The protein is also found in the neurofibrillary tangles and senile plaques in the brain lesions of Alzheimer’s disease. Whether or not it contributes to the pathology of Alzheimer’s disease is not confirmed.

Double distilled water is recommended to adjust the final concentration to 1.00 mg/mL.

alpha1-antitrypsin deficiency disorder, Alzheimer’s disease