Tau Protein (Thr181 Phosphorylated)

Human Thr181 phosphorylated Tau

This antibody recognizes the above mentioned peptide and its KLH conjugate, but not recognizes KLH alone. The antibody detected a 46kD band in mouse brain tissue lysate.

Human, mouse

Tau is a highly soluble microtubule associated protein found in high concentration in neuron of central nervous system. The main function of the protein is stabilizing the microtubule in nerve fibre (axon). There are six tau isoforms which are formed by alternate splicing. Hyperphosphorylation of Tau protein results in aggregation and formation of neurofibrillary tangles, which is significantly associated with cognitive impairment in Alzheimer’s disease. Tau Thr181 phosphorylation has been used as a biomarker for the differentiation of Alzheimer’s disease and other primary dementia such as dementia with Lewy bodies.

Double distilled water is recommended to adjust the final concentration to 1.00mg/mL. Avoid repeated freeze and thaw cycle.

Alzheimer’s disease and other neurodegenerative diseases