Anti-RelB Antibody [17.3]

Mouse monoclonal [17.3] antibody to Rel B.

Recombinant protein derived from C-terminus of human RelB protein.

Supplied in Phosphate Buffered Saline with 0.1% Sodium Azide.

ICC: 1 µg/ml, IF: 1 µg/ml, IHC-P: 1:10 - 1:50, WB: 1 - 2 µg/ml

This antibody recognises the transcription factor RelB, also known as I-Rel. RelB is encoded by the v-rel avian reticuloendotheliosis viral oncogene homolog B gene and is a critical component of the NF-kappa-B pathway.Upon cleavage of the NF-kappa-B p105 and p100 subunits into the NF-kappa-B p50 and p52 subunits, RelB forms RelB-p50 and RelB-p52 heterodimers. These dimers act as activators of transcription by binding to kappaB sites present on DNA. RelB-p50 and RelB-p52 binding induces the expression of genes mediating immune responses, inflammation and apoptosis. Misregulation of the NF-kappa-B pathway has been implicated in a variety of disease states including autoimmunity and cancer. As the NF-kappa-B pathway has been demonstrated to be constitutively active in a large group of tumors, developing NF-kappa-B inhibitors has emerged as a new cancer therapy approach (Chaturverdi et al. 2011 and Baud and Karin et al. 2009).