Anti-Aggrecan Antibody [7E1]

Aggrecan

Mouse monoclonal [7E1] antibody to Aggrecan.

Purified human articular cartilage aggrecan.

Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.

This antibody recognises human aggrecan, a proteoglycan and member of the aggrecan/versican proteoglycan family, which forms a major component of the extracellular matrix (ECM) of both cartilage and the central nervous system (CNS).A panel of core protein-directed antibodies against human aggrecan, revealed the distribution of different aggrecan isoforms within the CNS, and sub-divided the isoforms into clusters 1-5 accordingly. There is a difference in the relative abundance of these isoforms when comparing brain and cartilage tissues. recognises a ~205 kDa trypsin derived fragment of aggrecan.Note: Originally described as being of the isotype IgM, clone 7E1 was found to be unstable and was re-cloned by the originator and the new stable sub-clone was confirmed as being an IgG1.