Anti-VEGF Antibody [4B2-8]

Mouse monoclonal [4B2-8] antibody to VEGFA.

Highly purified recombinant human VEGF165.

Supplied in Phosphate Buffered Saline.

ELISA: 2.0 - 4.0 µg/ml, Functional Assays: 0.1 - 0.2 µg/ml, WB: 0.25 - 0.50 µg/ml

This antibody recognises human Vascular endothelial growth factor A , also known as VEGF-A or Vascular permeability factor. VEGF-A is a 206 amino acid ~45 kDa disulphide linked homodimeric heparin-binding cytokine and member of the PDGF/VEGF growth factor family, which exists as several splice variants of the VEGF gene, and is a potent stimulator of angiogenesis of both normal and cancerous cells, and acts as a regulator of vasculogenesis.The functional forms of VEGF are classified according to the number of amino acid residues within a constitutive polypeptide chain e.g VEGF165, and all VEGF family members act through binding to the tyrosine kinase receptors VEGFR-1 (Flt-1) and VEGFR-2 (KDR/CD309), whilst the closely-related VEGF-C and VEGF-D, can also bind to VEGFR-3 (Flt-4).