Anti-CD49d Antibody [HP2/1]

Mouse monoclonal [HP2/1] antibody to Integrin alpha 4 / CD49D.

JM leukaemia line.

Supplied in Phosphate Buffered Saline with 0.1% Sodium Azide.

This antibody recognises human CD49d also known as integrin alpha-4 or VLA-4 subunit alpha. CD49d is a ~150kDa single pass type 1 transmembrane glycoprotein with seven FG-GAP repeats, characteristic of alpha integrins, in its extracellular domain. CD49d can be proteolytically cleaved to yield framents of 80 and 70kDa. CD49d associates with either CD29 to form VLA-4 or with Integrin beta-7 to form the Peyer's patch-specific homing receptor LPAM-1, involved in the lymphocyte migration and homing to gut-associated lymphoid tissue (Sackstein 2006) through its interaction with MadCam-1, preferentially expressed on Peyer’s patch high endothelial venules and postcapillary venules in lamina propria. Mouse anti human CD49d, clone HP2/1 binds to both intact and the 80kDa fragment of integrin alpha-4. CD49d is expressed on monocytes, T cells, B cells, thymocytes and Langerhans cells. Mouse anti Human CD49d, clone HP2/1 can be used in assays of VLA-4 mediated adhesion and its interaction with the VCAM-1 structure and inhibits cell binding to soluble VCAM-1.