Anti-Siglec-7 Antibody [S7.7]

Siglec 7

Mouse monoclonal [S7.7] antibody to Siglec 7.

Siglec-7 3T3 transfected cells.

Supplied in Phosphate Buffered Saline.

Flow Cytometry: 1:25 - 1:200, Use 10µl of the suggested working dilution to label 10⁶ cells.

This antibody recognises human Sialic acid-binding Ig-like lectin 7, otherwise known as CD328, a putative adhesion molecule and member of the Ig superfamily, predominantly expressed by both resting and activated natural killer (NK) cells, and also at lower levels by monocytes, granulocytes, monocyte-derived macrophages and dendritic cells, and a small population of CD8+ memory T cells. Classed as a CD33-related Siglec, Siglec-7 preferentially binds to glycoconjugates containing alpha-2, 3- or alpha-2, 6-linked sialic acid, and acts as a novel inhibitory receptor for NK cells, mediating the inhibition of NK cell cytotoxicity, and implicated in the regulation of NK cell and T cell activation, and hematopoiesis. Mouse anti Human Siglec-7 antibody, cloneS7.7 is a blocking antibody , and has been shown to recognize Siglec-7 in Rhesus monkey.