Anti-RANTES Antibody

ArtNr	ANTI-A283833-100
Hersteller	Antibodies.com
Menge	100 ug
Kategorie	Antibodies Immunohistochemistry Western Blot ELISA Primary Antibodies Immunostaining Functional Assays
Typ	Antibody Primary
Format	Lyophilized
Applikationen	WB, ELISA, IHC-P, FA
Specific against	Human (Homo sapiens)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Manufacturer - Targets	RANTES
Storage Conditions	Lyophilized: Store at -20°C. Reconstituted: Store undiluted at -20°C, avoid freeze / thaw cycles. Storage in frost free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.
Product Description	Rabbit polyclonal antibody to RANTES.
Clonality	Polyclonal
Immunogen	Recombinant human RANTES.
Concentration	1 mg/ml after reconstitution.
Manufacturer - Formulation	Supplied in Phosphate Buffered Saline.
Recommended dilutions	ELISA: 0.5 µg/ml - 2 µg/ml, Functional Assays: 5.0 µg/ml - 7.0 µg/ml, WB: 0.1 µg/ml - 0.2 µg/ml
Manufacturer - Specificity	This antibody recognises human RANTES (regulated upon activation, normal T cell expressed and secreted), otherwise known as CCL5, a 68 amino acid CC- chemokine involved in T cell activation and cell recruitment, expressed by cytotoxic (CD8+) T cells (CTLs), macrophages, keratinocytes and endothelial cells.RANTES acts as a chemoattractant for monocytes, CD4+/CD45RO+ memory T cells, basophils and eosinophils, thorough binding to chemokine (C-C motif) receptor 1 (CCR1), CCR3 and CCR5. Both CCR3 and CCR5 are known co-receptors for the entry of HIV viruses into target cells and the binding of RANTES to CCR3 on CTLs has been shown to enhance HIV-1-specific cytotoxicity, whilst binding to CCR5 inhibits membrane fusion and hence HIV entry.
Reconstitution	Reconstitute with 0.1 ml of distilled water. For long term storage the addition of 0.09% sodium azide is recommended. For functional studies do not add sodium azide.

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Menge: 100 ug

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Lieferung vsl. bis 13.11.2025

Express-Lieferung: 3 Tage sparen

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