CD11b polyclonal antibody

P11215(Human)

Integrin alphaM, also designated complement component receptor-3 alpha, CD11b (p170), macrophage antigen a polypeptide, cell surface glycoprotein Mac-1 a subunit, MAC1A, MO1A and ITGAM) is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin alphaM combines with the Integrin beta2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin alphaM/beta2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles.

ProA affinity purified

CD11b polyclonal antibody detects endogenous levels of CD11b protein.

For research use only, not for use in diagnostic procedure.