Synuclein alpha polyclonal antibody

P37840(Human) O55042(Mouse)

The synuclein family members, including alpha-synuclein (also designated NACP for non-beta-Amyloid component) and beta-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. alpha-synuclein is localized to neuronal cell bodies and synapses. alpha-synuclein was first identified as a component of Alzheimer's disease amyloid plaques. Abnormal platelet function in Alzheimer's disease has been demonstrated. During megakaryocytic differentiation alpha-synuclein has been found to be upregulated, while beta-synuclein is downregulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of alpha-synuclein has been found in patients with early onset Parkinson's disease.

ProA affinity purified

Synuclein alpha polyclonal antibody detects endogenous levels of Synuclein alpha protein.

For research use only, not for use in diagnostic procedure.