Elastin IHC Antibody

Description Elastin is a major structural protein of tissues such as aorta, which must expand rapidly and recover completely. Elastin chains are cross-linked together into an extensible 3D network. It is a molecular determinant of late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle. Defects in elastin are a cause of autosomal dominant cutis laxa. Catalog Number IW-MA1038 Quantity 9 ml Host Mouse Clone IL-4 Isotype Mouse IgG1 Immunogen Bovine alpha-elastin. Purity Purified by the goat anti-mouse IgG affinity chromatography Conjugate Unconjugated Species Reactivity Human, dog, guinea pig. Not tested in other species. Positive Control Skin, kidney, small intestine. Cellular Localization Extracellular Form Ready to use solution in PBS with stabilizer and 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted. Storage Store at 2-8 CC. Do not freeze. Applications IHC-P: Proteolytic Induced Epitope Retrieval (PIER) (Proteinase K) required on formalin fixed paraffin embedded tissue sections. IHC-Fr: Not tested. ICC: Not tested. Limitations This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user. Precautions Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes. References 1. Rosenbloom, J. : Personal Communication. Philadelphia, Pa., 4/1984. 2. Urban, Z.; Riazi, S.; Seidl, T. L.; Katahira, J.; Smoot, L. B.; Chitayat, D.; Boyd, C. D.; Hinek, A. : Connection between elastin haploinsufficiency and increased cell proliferation in patients with supravalvular aortic stenosis and Williams-Beuren syndrome. Am. J. Hum. Genet. 71: 30-44, 2002. 3. Uitto, J.; Christiano, A. M.; Kahari, V.-M.; Bashir, M. M.; Rosenbloom, J. : Molecular biology and pathology of human elastin. Biochem. Soc. Trans. 19: 824-829, 1991.