Tau IHC Antibody

Description The microtubule-associated proteins (MAPs) coassemble with tubulin into microtubules in vitro. Microtubule-associated protein tau appears to beenriched in axons.Tau is composed of 352 to 441 amino acids. The isoforms differ from each other by the presence or absence of29-amino acid or 58-amino acid inserts located in the N terminus anda 31-amino repeat located in the C terminus. Tau is important in establishing and maintaining neuronal morphology and is a major component of the neurofibrillary tangles (NFTs) characteristic of Alzheimer's brain. Microtubule-associated protein tau (MTBT1) is mapped to chromosome 17q21. Catalog Number IW-MA1093 Quantity 9 ml Host Mouse Clone TAU-93 Isotype Mouse IgG1 Immunogen Bovine microtubule-associated proteins (MAPs). Purity Purified by the goat anti-mouse IgG affinity chromatography Conjugate Unconjugated Species Reactivity Human, mouse, rat. Not tested in other species. Positive Control Alzheimer's brain tissue (neurofibrillary tangles, senile plaques) Cellular Localization Cytoplasmic Form Ready to use solution in PBS with stabilizer and 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted. Storage Store at 2-8 CC. Do not freeze. Applications IHC-P: Heat induced epitope retrieval is required on formalin fixed paraffin embedded sections. IHC-Fr: Not tested. ICC: Not tested. Limitations This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user. Precautions Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes. References 1. Andreadis, A.; Brown, W. M.; Kosik, K. S. : Structure and novel exons of the human tau gene. Biochemistry 31: 10626-10633, 1992. 2. Donlon, T. A.; Harris, P.; Neve, R. L. : Localization of microtubule-associated protein tau (MTBT1) to chromosome 17q21. (Abstract) Cytogenet. Cell Genet. 46: 607, 1987.