TH (Tyrosine hydroxylase) IHC Antibody

Description Tyrosine hydroxylase is involved in the conversion of phenylalanine to dopamine. As the rate-limiting enzyme in the synthesis of catecholamines, tyrosine hydroxylase has a key role in the physiology of adrenergic neurons.Human TH gene contains 13 primary exons and spans approximately 8 kb.TH is in the 11p15.5 region. Catalog Number IW-MA1100 Quantity 9 ml Host Mouse Clone TH-100 Isotype Mouse IgG1 Immunogen Rat tyrosine hydroxylase (TH). Purity Purified by the goat anti-mouse IgG affinity chromatography Conjugate Unconjugated Species Reactivity Human, rat. Not tested in other species. Positive Control Brain (striatum, substantia nigra) Cellular Localization Cytoplasmic of dopamine neurons Form Ready to use solution in PBS with stabilizer and 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted. Storage Store at 2-8 CC. Do not freeze. Applications IHC-P: Heat induced epitope retrieval is required on formalin fixed paraffin embedded sections. IHC-Fr: Formalin or acetone fixed frozen sections. ICC: Not tested. Limitations This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user. Precautions Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes. References 1. Brilliant, M. H.; Niemann, M. M.; Eicher, E. M. : urine tyrosine hydroxylase maps to the distal end of chromosome 7 within a region conserved in mouse and man. J. Neurogenet. 4: 259-266, 1987. 2. Craig, S. P.; Buckle, V. J.; Craig, I. W.; Lamouroux, A.; Mallet, J. : Localization of the human tyrosine hydroxylase gene to chromosome 11p15. (Abstract) Cytogenet. Cell Genet. 40: 610 only, 1985. 3. Craig, S. P.; Buckle, V. J.; Lamouroux, A.; Mallet, J.; Craig, I. : Localization of the human tyrosine hydroxylase gene to 11p15: gene duplication and evolution of metabolic pathways. Cytogenet. Cell Genet. 42: 29-32, 1986.