Anti-Human Beta-Defensin 2-Biotin - 50 µg

Quality Tested by Leinco Western Blotting: To detect Human BD-2 this biotin conjugate can be used at a concentration of 0.1-0.2 µg/ml. This biotin conjugate should be used in conjunction with compatible second-step reagents such as PN:A106 and a chromogenic substrate such as PN:T343. The detection limit for Human BD-2 is 10 ng/lane under either reducing or non-reducing conditions. The sensitivity of detection may increase up to 50 fold when a chemiluminescent substrate is used. A suitable Western blotting control is PN:B113.

Beta-Defensin 2

Next Day Ambient

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. In addition to their direct antimicrobial activities, they are chemoattractant towards immature dendritic cells and memory T cells. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence and, in the case of BD-1, a propeptide region. Beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. Human, rabbit and guinea-pig beta-defensins, as well as human beta-defensin-2 (hBD2), induce the activation and degranulation of mast cells, resulting in the release of histamine and prostaglandin D2.

Beta-Defensin 2

AB_2828178

Purified Recombinant Human BD-2 (> 98%)

Polyclonal Antibody, Beta-Defensin-2, Skin-antimicrobial peptide 1 [SAP1], BD-2, Human, Anti-Human Beta-Defensin-2-Biotin, BD-2, betaDefensin 2, beta-Defensin 2, DEFB2, DEFB-2, DEFB2DEFB102, DEFB4A, DEFB4B, DEFB4beta-defensin 4A, Defensin beta 2Skin-antimicrobial peptide 1, defensin beta 4, defensin beta 4A, HBD-2, SAP-1, SAP1BD-2