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Anti-Mouse CD127 (IL-7Rα) - Purified - 0.5 mg

Anti-Mouse CD127 (IL-7Rα) - Purified - 0.5 mg

ArtNr	LEIN-C2133-0.5mg
Hersteller	Leinco Technologies
Menge	0.5 mg
Kategorie	Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Western Blot Immunofluorescence Primary Antibodies Functional Assays
Typ	Antibody Monoclonal
Applikationen	WB, FC, IF, IP, IHC, FA
Clon	A7R34
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Citations	1. Fry TJ et al. (2005) J Immunol. 174: 6571 2. Murre C et al. (2002) Embo J. 21: 103
NCBI	16197
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Applications	FA, FC, IF Staining, IHC FF, IP, WB
Manufacturer - Category	Primary Monoclonal Antibodies>Surfacetag Mouse CD Markers
Manufacturer - Targets	CD127
Country of Origin	USA
Shipping Temperature	Next Day 2 - 8°C
Storage Conditions	This purified antibody is stable when stored at 2-8°C. Do not freeze.
Product Description	CD127 (IL7R-α) is a 60-90 kD type I cytokine receptor involved in the regulation of lymphopoiesis. The active receptor is an α/γ chain heterodimer. The common γ chain, which also associates with the IL-2 receptor, serves mainly to activate signal transduction via the IL7R complex. CD127 also interacts with the Thymic Stromal Lymphopoietin Receptor (TSLPR). CD127 determines signaling events via its association with cytoplasmic signaling molecules and has been reported to be a useful marker for identifying memory and effector T cells.
Background	CD127 (IL7R-α) is a 60-90 kD type I cytokine receptor involved in the regulation of lymphopoiesis. The active receptor is an α/γ chain heterodimer. The common γ chain, which also associates with the IL-2 receptor, serves mainly to activate signal transduction via the IL7R complex. CD127 also interacts with the Thymic Stromal Lymphopoietin Receptor (TSLPR). CD127 determines signaling events via its association with cytoplasmic signaling molecules and has been reported to be a useful marker for identifying memory and effector T cells.
Other Applications Reported In Literature	FA IF Staining IHC (Frozen) IP WB
PubMed	CD127
Ligand/Receptor	IL-7
Manufacturer - Research Area	Immunology
Manufacturer - Specificity	Clone A7R34 recognizes an epitope on mouse CD127.
RRID	AB_2829215
Concentration	0.5 mg/ml
Formulation	This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Antigen Distribution	IL-7Rα is expressed on bone marrow lymphoid precursors, pro-B cells, monocytes/macrophages, NK-cells, naïve T cells, memory CD4+ and CD8+ T cells, intestinal colorectal and renal carcinoma cell lines, and keratinocytes.
Immunogen	Recombinant Mouse IL-7ra
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, CD127, IL-7Rα, Interleukin-7 receptor alpha, IL-7Rα chain, , CD127, Mouse, Anti-Mouse CD127 (IL-7Rα) - Purified, Flow Cytometry, Immunoprecipitation, Western Blotting, Immunohistochemistry, Immunofluorescence microscopy, Immunology, thymocytes, IL-2, IL-4, IL-9, IL-13, IL-15

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LEIN-C2133-0.5mg-safety-datasheet.pdf