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Anti-Mouse IL-2 [Clone JES6-5H4] – Purified - 0.5 mg

Anti-Mouse IL-2 [Clone JES6-5H4] – Purified - 0.5 mg

ArtNr	LEIN-I-1039-0.5mg
Hersteller	Leinco Technologies
Menge	0.5 mg
Kategorie	Antibodies Immunohistochemistry Immunoprecipitation Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	IP, IHC
Clon	JES6-5H4
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Citations	1. Schachter, J. et al. (2009) Cytotherapy 11: 206 2. Sodora, DL. et al. (2009) Curr HIV Res. 7: 83 3. Alcocer-Varela, J. et al. (2009) Autoimmun Rev. 9(1):34-9.
NCBI	16183
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	IHC FFPE, IP
Manufacturer - Category	Primary Monoclonal Antibodies>Growth Factors and Cytokines
Manufacturer - Targets	IL-2
Shipping Temperature	Next Day Ambient
Storage Conditions	This purified antibody is stable when stored at 2-8°C. Do not freeze.
Product Description	IL-2 is a 17.2 kD cytokine signaling protein that is the regulator of the proliferative and suppressive phases of the immune response, and stimulates growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendrocytes. It functions as a primary regulator of T cell homeostasis. Il-2 regulates the activities of white blood cells and plays a role in the immune system via “self” and “non-self” discrimination. IL-2 is a prime candidate in immunotherapeutics for both increasing T cell levels/function and for augmenting vaccine-elicited viral-specific T cell responses. IL-2 signal can be transduced via 3 different signaling pathways that include the JAK-STAT, PI3K/Akt/mTOR and MAPK/ERK pathways. Aldesleukin is a form of recombinant interleukin-2 for the treatment of cancers including malignant melanoma and renal cell cancer. Furthermore, there is additional therapeutic potential for IL-2 mAb use with transplants and autoimmune disease.
Background	IL-2 is a 17.2 kD cytokine signaling protein that is the regulator of the proliferative and suppressive phases of the immune response, and stimulates growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendrocytes. It functions as a primary regulator of T cell homeostasis. Il-2 regulates the activities of white blood cells and plays a role in the immune system via “self” and “non-self” discrimination. IL-2 is a prime candidate in immunotherapeutics for both increasing T cell levels/function and for augmenting vaccine-elicited viral-specific T cell responses. IL-2 signal can be transduced via 3 different signaling pathways that include the JAK-STAT, PI3K/Akt/mTOR and MAPK/ERK pathways. Aldesleukin is a form of recombinant interleukin-2 for the treatment of cancers including malignant melanoma and renal cell cancer. Furthermore, there is additional therapeutic potential for IL-2 mAb use with transplants and autoimmune disease.
PubMed	IL-2
Manufacturer - Research Area	Immunology, Other Molecules
Manufacturer - Specificity	Clone JES6-5H4 recognizes an epitope on mouse IL-2.
RRID	AB_2830370
Concentration	0.5 mg/ml
Formulation	This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative.
Immunogen	Purified Recombinant Mouse IL-2 (> 98%)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Monoclonal Antibody, Interleukin-2, TCGF, Lymphokine, T-Cell Growth Factor, Aldesleukin, JES6-5H4, IL-2, Mouse, Anti-Mouse IL-2 - Purified, EDF, KHF, MAF-C I, TDF, IL2, IP, IHC

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LEIN-I-1039-0.5mg-safety-datasheet.pdf