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Anti-Human TGF-α [Polyclonal] – Biotin - 50 µg

Anti-Human TGF-α [Polyclonal] – Biotin - 50 µg

ArtNr	LEIN-T186-50ug
Hersteller	Leinco Technologies
Menge	50 ug
Kategorie	Antibodies Western Blot ELISA Primary Antibodies Immunostaining
Typ	Antibody Primary
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens)
Host	Caprine
Citations	1. Taylor, HS. et al. (2009) Semin Reprod Med.27(1):62-79 2. Lamaroon, A. et al. (2002) J Dental Research 75:1534 3. Loughlin, S. et al. (2002) Proc Natl Acad Sci USA 97:14686 4. Fuchs, E. et al. (1991) Genes & Dev. 5:714
NCBI	7039
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Applications	ELISA Det, WB
Manufacturer - Category	Polyclonal Antibodies>Biotin Growth Factors & Cytokines
Manufacturer - Targets	TGF-α
Country of Origin	USA
Shipping Temperature	Next Day Ambient
Storage Conditions	The lyophilized, biotinylated antigen affinity purified polyclonal antibody can be stored desiccated at -20°C to -70°C for up to twelve months from date of receipt. The reconstituted biotin conjugate can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted conjugate, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. No detectable loss of activity was observed after six months.
Product Description	Transforming growth factor alpha (TGF-α) is thought to be the major autocrine factor controlling growth in epidermal cells.1 It plays an important role in cell proliferation during embryogenesis.2 It also stimulates neural cell proliferation in the adult injured brain.3 TGF-alpha is an oncogenic growth factor which drives estrogen independent breast tumor proliferation via an autocrine loop.4 TGF-alpha which normally suppresses tumours can actually be used by cancer cells to enhance their ability to spread. It is present in high levels in around half of all breast tumours, and these tumours tend to be more aggressive and more likely to spread to the lungs. It has been shown that TGF-alpha can prompt breast cancer cells to make another cytokine called angiopoietin-like 4 (ANGPTL4), which helps the cells to spread through the bloodstream.5
Background	Transforming growth factor alpha (TGF-α) is thought to be the major autocrine factor controlling growth in epidermal cells.¹ It plays an important role in cell proliferation during embryogenesis.² It also stimulates neural cell proliferation in the adult injured brain.³ TGF-alpha is an oncogenic growth factor which drives estrogen independent breast tumor proliferation via an autocrine loop.⁴ TGF-alpha which normally suppresses tumours can actually be used by cancer cells to enhance their ability to spread. It is present in high levels in around half of all breast tumours, and these tumours tend to be more aggressive and more likely to spread to the lungs. It has been shown that TGF-alpha can prompt breast cancer cells to make another cytokine called angiopoietin-like 4 (ANGPTL4), which helps the cells to spread through the bloodstream.⁵
PubMed	TGF-α
Manufacturer - Specificity	Goat Anti-Human Transforming Growth Factor-Alpha (TGF-α) recognizes Human TGF-α. This antigen affinity purified polyclonal antibody was purified using a proprietary chromatographic technique that includes covalently immobilizing the antigen proteins or peptides to agarose based beads. This purification method enhances specificity, reduces nonspecific binding of extraneous IgG and provides you with the most reliable reagent available for your early discovery research.
RRID	AB_2831838
Formulation	This biotinylated antigen affinity purified polyclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.4 containing 50 µg of bovine serum albumin per µg of antibody with no calcium, magnesium, or preservatives present.
Immunogen	Purified Recombinant Human TGF-α (Accession # P01135)
Additional Information	Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.
Keywords	Polyclonal Antibody, Transforming Growth Factor Alpha, Sacroma Growth Factor, TGF-Type I, ETGF, MDGF-2, TCGF, TGFα, Human TGFa, Anti-Human TGF-α-Biotin, Human TGFα, TGFa, protransforming growth factor alpha, TFGA, TGFA, TGFalpha, TGF-alpha, transforming growth factor, alpha, transforming growth factor-alpha

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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LEIN-T186-50ug-safety-datasheet.pdf