SARS-CoV-2 (COVID-19) Nucleocapsid Antibody [7A7]

WB(1:500-2000), ELISA(1:5000-1000)

Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.

≥1 mg/mL

Recombinant SARS-CoV-2 N protein (His-tag)

Nucleocapsid phosphoprotein

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only