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SARS-CoV-2 Nucleocapsid Antibody

SARS-CoV-2 Nucleocapsid Antibody

ArtNr	PRS-10-065-0.1mg
Hersteller	ProSci
Menge	0.1 mg
Kategorie	Oncology Infectious Diseases Viral Infections Coronavirus (COVID-19) Antibodies Flow Cytometry Immunohistochemistry Western Blot ELISA Primary Antibodies By Organ Testicular & Prostate Cancer
Typ	Antibody Primary
Format	Liquid
Applikationen	WB, IHC, ELISA
Clon	1C7C7
Specific against	other
Isotype	IgG2a
Konjugat/Tag	Unconjugated
Citations	Ni L, Ye F, Cheng ML, et al. Immunity. 52(6):971-977.e3. 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), is an enveloped, single-stranded, positive-sense RNA virus that belongs to the Coronaviridae family 1. The SARS-CoV-2 genome, which shares 79.6% identity with SARS-CoV, encodes four essential structural proteins: the spike (S), envelope (E), membrane (M), and nucleocapsid protein (N) 2. The N protein is 46 kDa and consists of two highly conserved structural domains, the N-terminal domain (NTD) and C-terminal domain (CTD), connected by a linker region. The NTD and CTD are involved in RNA binding and self-oligomerization, respectively 3, 4. The primary function of the N protein is to bind to and package the viral RNA genome into a helical ribonucleoprotein complex 5. The N protein is also involved in other critical steps of the viral life cycle, including transcription, replication, and modulating infected cell signaling pathways 6, 7. The N protein is abundantly expressed during infection and is highly conserved, sharing 90% amino acid homology with the SARS-CoV N protein 8. It is also immunogenic, and antibodies 8,9 and memory T cells 10, 11 targeting the N protein are present in the sera of convalescent COVID-19 patients, identifying the N protein as a suitable candidate for vaccine development and diagnostic assays. Diagnostic assays based on the N protein effectively detect antibodies in the sera of patients infected with SARS-CoV-2 12. The N protein also contributes to immune evasion by antagonizing antiviral RNAi 13, suggesting its potential value as a targeted therapeutic. Zhou, P., Yang, X., Wang, X. et al. Nature 579, 270–273. 2020. Wu, F., Zhao, S., Yu, B. et al. Nature 579, 265–269. 2020. Kang S, Yang M, Hong Z, et al. Acta Pharm Sin B. 10.1016/j.apsb.2020.04.009. 2020. Chang CK, Sue SC, Yu TH, et al. J Biomed Sci. 13(1):59-72. 2006. Hsieh PK, Chang SC, Huang CC, et al. J Virol. 79(22):13848-13855. 2005. Surjit M, Lal SK. Infect Genet Evol. 8(4):397-405. 2008. Hurst KR, Ye R, Goebel SJ, Jayaraman P, Masters PS. J Virol. 84(19):10276-10288. 2010. Guo L., Ren L., Yang S., et al. Clinical Infectious Diseases: an Official Publication of the Infectious Diseases Society of America. 2020. To K.K., Tsang O.T., Leung W.S., et al. Lancet Infect. Dis. 2020.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	SARS-CoV-2 Nucleocapsid, SARS-CoV-2 Nucleoprotein, Protein N, SARS-CoV N Protein
Lieferbar
Manufacturer - Applications	ELISA, IHC, WB (Quality Tested by ProSci); FC (Other applications as reported in literature)
Manufacturer - Isotype	Mouse IgG2a
Shipping Temperature	blue ice or room temperature
Storage Conditions	Functional grade preclinical antibodies may be stored sterile as received at 2-8° C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80° C. Avoid Repeated Freeze Thaw Cycles.
Manufacturer - Research Area	Infectious Disease, COVID-19
Protein Gi #	SARS-CoV-2
Purification	>95% by SDS Page
Concentration	>1.0 mg/ml
Buffer	This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium, calcium or preservatives added.
Immunogen	Recombinant nucleoprotein of SARS-CoV (severe acute respiratory syndrome).The nucleocapsid protein is expressed in the internal nucleocapsid of SARS-CoV-2.
Clonality	Monoclonal
NCBI Official Name	N
NCBI Organism	nucleocapsid phosphoprotein
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	43740575

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Menge: 0.1 mg

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Lieferung vsl. bis 02.10.2025

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