ETV1 Antibody

Neuroscience, Signal Transduction, Stem Cell, Transcription

IHC: 1:50 - 1:200

IF: 1:50 - 1:200

Polyclonal

Unconjugated

Store at -20˚ C. Avoid freeze / thaw cycles.

None

2115

ETV1

Homo sapiens

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Ewing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Immunohistochemistry of paraffin-embedded human breast cancer using ETV1 antibody (14-903) at dilution of 1:100 (40x lens).

Immunofluorescence analysis of A549 cells using ETV1 antibody (14-903).