CHN2 Antibody

ArtNr	PRS-30-773-100ul
Hersteller	ProSci
Menge	100 ul
Kategorie	Neuroscience Neural Signaling Antibodies Cell Biology Cytoskeleton Western Blot ELISA Primary Antibodies small GTPases Rho Subfamily
Typ	Antibody Polyclonal
Format	Liquid
Applikationen	WB, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Konjugat/Tag	Unconjugated
Citations	Uhl, G.R., (2008) Arch. Gen. Psychiatry 65 (6), 683-693.
NCBI	CHN2
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	CHN2, ARHGAP3, BCH, MGC138360, RHOGAP3, CHN2-3
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Manufacturer - Applications	CHN2 antibody can be used for detection of CHN2 by ELISA at 1:62500. CHN2 antibody can be used for detection of CHN2 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50, 000 - 100, 000.
Shipping Temperature	blue ice or room temperature
Storage Conditions	For short periods of storage (days) store at 4°C. For longer periods of storage, store CHN2 antibody at -20°C. As with any antibody avoid repeat freeze-thaw cycles.
Molecular Weight	38 kDa
Manufacturer - Research Area	Cancer
Background	CHN2 is a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. CHN2 plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men.This gene is a member of the chimerin family and encodes a protein with a phorbol-ester/DAG-type zinc finger, a Rho-GAP domain and an SH2 domain. This protein has GTPase-activating protein activity that is regulated by phospholipid binding and binding of diacylglycerol (DAG) induces translocation of the protein from the cytosol to the Golgi apparatus membrane. The protein plays a role in the proliferation and migration of smooth muscle cells. Decreased expression of this gene is associated with high-grade gliomas and breast tumors, and increased expression of this gene is associated with lymphomas. Mutations in this gene have been associated with schizophrenia in men. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Protein Gi #	91106928
Purification	Antibody is purified by peptide affinity chromatography method.
Positive Control 1	PRS-XBL-10409-0.1mg
Concentration	Batch dependent
Buffer	Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Immunogen	Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CHN2.
Clonality	Polyclonal
NCBI Official Name	chimerin 2
NCBI Organism	Homo sapiens
Disclaimer	This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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Menge: 100 ul

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Lieferung vsl. bis 02.10.2025

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