LSD1 / KDM1 Antibody

Primary Antibodies

Aliquot and Store at -20˚ C. Avoid freez-thaw cycles.

LSD1 (Lysine-specific demethylase 1), also called KDM1 (lysine (K)-specific demethylase 1A), is the first histone demethylase to be identified and regulates transcription via demethylation of lysines 4 and 9 of Histone H3. It negatively regulates pro-inflammatory cytokine expression by interacting with the genes promoter region. It also plays a role in tumor development where overexpression of LSD1 correlates with a poor prognosis. It is upregulated in cancers of the bladder, breast, lung, colon, and GI tract as well as neuroblastoma and cells of mesenchymal origin such as chondrosarcoma, osteosarcoma, rhabdomyosarcoma and Ewing's sarcoma (Bennani-Baiti et al, 2012).

None

0.5 mg/mL

Western blot: 0.5-2 ug/ml
Provided assay concentrations are suggestions only, LSD1 / KDM1 antibody titration may be required for optimal results.

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher