TAB3 Antibody

Western blot: 4-8 ug/ml

Provided assay concentrations are suggestions only, antibody titration may be required for optimal results.

Aliquot and Store at -20°C. Avoid freez-thaw cycles.

TAB3, a TAB2-like protein, is a mediator of TAK1 activation in IL-1 and TNF signaling. IL-1 and TNF are cytokines involved in the inflammation process, initiating signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (MAPKs). TAB3 functions as an adapter, linking TAK1 and TRAF6 or TRAF2. This kinase complex phosphorylates IkB, which keeps NF-kB inactive and sequestered in the cytoplasm. Phosphorylation leads to IkB degradation, activating NF-kB, which translocates to the nucleus, binds to DNA response elements and can begin multiple signaling cascades.

0.5 mg/mL

A recombinant protein fragment from the N-terminal region of human TAB3 was used as the immunogen for this antibody.

TGF-beta activated kinase 1/MAP3K7 binding protein 3

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.