Recombinant CD45RB Antibody [PTPRC/1783R]

IgG, k

Aliquot and Store at 2-8˚ C. Avoid freez-thaw cycles.

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45RB is expressed on mature B-lymphocytes and the majority of lymphomas and leukemias of B-cell origin. This antigen is also expressed on the surface of cells of myeloid lineage.

Recombinant

Protein A affinity chromatography

PBS with 0.1 mg/ml BSA and 0.05% sodium azide

Human B lymphocytes were used as immunogen for this recombinant CD45RB antibody.

protein tyrosine phosphatase, receptor type, C

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.