FLIP Antibody [NF6]

Immunohistochemistry (paraffin sections) . Western Blot (1:1000).

Stable for at least 1 year after receipt when stored at -20°C.

FLIP is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells and acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. FLIP lacks enzymatic (caspase) activity. FLIP is highly expressed in skeletal muscle, pancreas, heart, kidney, placenta and peripheral blood leukocytes.

1 mg/ml

Recombinant human FLIP (aa 1-480).

CASP8 and FADD-like apoptosis regulator

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.