IGF-BP5 Antibody (biotin)

Primary Antibodies, Antibody Pairs

IGF-BP5 antibody is stable for at least 2 years from date of receipt at -20˚ C. The reconstituted antibody is stable for at least two weeks at 2-8˚ C. Frozen aliquots are stable for at least 6 months when stored at -20˚ C. Avoid repeated freeze-thaw cycles.

IGF-BP5 is one of a family of proteins that bind to insulin-like growth factors (IGFs). IGFB-P5 is a multifunctional protein which acts not only as a traditional binding protein but also functions as a growth factor independent of IGFs to stimulate bone formation. Currently there are seven named IGF-BPs that form high affinity complexes with both IGFI and IGFII. IGF-BP5 is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGFI on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGF-BP5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGF-BP5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development.

None

batch dependent

Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hIGF-BP5. Human IGF-BP5 specific antibody was purified by affinity chromatography and then biotinylated.

insulin-like growth factor binding protein 5

This product is for research use only.