IL12B Antibody

Primary Antibodies

Blue Ice

37 kDa

IL12B is a subunit of interleukin 12, a cytokine
that acts on T and natural killer cells, and has a broad array of
biological activities. Interleukin 12 is a disulfide-linked
heterodimer composed of the 40 kD cytokine receptor like subunit
encoded by this gene, and a 35 kD subunit encoded by IL12A. This
cytokine is expressed by activated macrophages that serve as an
essential inducer of Th1 cells development. This cytokine has been
found to be important for sustaining a sufficient number of
memory/effector Th1 cells to mediate long-term protection to an
intracellular pathogen. Overexpression of this gene was observed in
the central nervous system of patients with multiple sclerosis
(MS), suggesting a role of this cytokine in the pathogenesis of the
disease. The promoter polymorphism of this gene has been reported
to be associated with the severity of atopic and non-atopic asthma
in children.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This IL12B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 264-290 amino acids from the C-terminal region of human IL12B.

Interleukin-12 subunit beta

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.