BARD1 Antibody

Primary Antibodies

Blue Ice

87 kDa

BARD1 is a protein which interacts with the
N-terminal region of BRCA1. In addition to its ability to bind
BRCA1 in vivo and in vitro, it shares homology with the 2 most
conserved regions of BRCA1: the N-terminal RING motif and the
C-terminal BRCT domain. The RING motif is a cysteine-rich sequence
found in a variety of proteins that regulate cell growth, including
the products of tumor suppressor genes and dominant protooncogenes.
This protein also contains 3 tandem ankyrin repeats. The
BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid
substitutions in BRCA1, implying that the formation of a stable
complex between these proteins may be an essential aspect of BRCA1
tumor suppression. This protein may be the target of oncogenic
mutations in breast or ovarian cancer.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This BARD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-131 amino acids from the N-terminal region of human BARD1.

BRCA1-associated RING domain protein 1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.