HP Antibody

Primary Antibodies

Blue Ice

45 kDa

This gene encodes a preproprotein, which is processed to
yield both alpha and beta chains, which subsequently combine as a
tetramer to produce haptoglobin. Haptoglobin functions to bind free
plasma hemoglobin, which allows degradative enzymes to gain access
to the hemoglobin, while at the same time preventing loss of iron
through the kidneys and protecting the kidneys from damage by
hemoglobin. Mutations in this gene and/or its regulatory regions
cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also
been linked to diabetic nephropathy, the incidence of coronary
artery disease in type 1 diabetes, Crohn's disease, inflammatory
disease behavior, primary sclerosing cholangitis, susceptibility to
idiopathic Parkinson's disease, and a reduced incidence of
Plasmodium falciparum malaria. A similar duplicated gene is located
next to this gene on chromosome 16. Multiple transcript variants
encoding different isoforms have been found for this gene.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This HP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-322 amino acids from the Central region of human HP.

Haptoglobin

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.