CCNH Antibody

Primary Antibodies

Blue Ice

38 kDa

The protein encoded by this gene belongs to the highly
conserved cyclin family, whose members are characterized by a
dramatic periodicity in protein abundance through the cell cycle.
Cyclins function as regulators of CDK kinases. Different cyclins
exhibit distinct expression and degradation patterns which
contribute to the temporal coordination of each mitotic event. This
cyclin forms a complex with CDK7 kinase and ring finger protein
MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2
kinases, thus functions as a CDK-activating kinase (CAK). This
cyclin and its kinase partner are components of TFIIH, as well as
RNA polymerase II protein complexes. They participate in two
different transcriptional regulation processes, suggesting an
important link between basal transcription control and the cell
cycle machinery. A pseudogene of this gene is found on chromosome
4. Alternate splicing results in multiple transcript variants.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Predicted species reactivity based on immunogen sequence: Monkey

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.