B3GALT5 Antibody

Rabbit Ig

Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

This gene is a member of the
beta-1, 3-galactosyltransferase (beta3GalT) gene family. This family
encodes type II membrane-bound glycoproteins with diverse enzymatic
functions using different donor substrates (UDP-galactose and
UDP-N-acetylglucosamine) and different acceptor sugars
(N-acetylglucosamine, galactose, N-acetylgalactosamine). The
beta3GalT genes are distantly related to the Drosophila Brainiac
gene and have the protein coding sequence contained in a single
exon. The beta3GalT proteins also contain conserved sequences not
found in the beta4GalT or alpha3GalT proteins. The carbohydrate
chains synthesized by these enzymes are designated as type 1,
whereas beta4GalT enzymes synthesize type 2 carbohydrate chains.
The ratio of type 1:type 2 chains changes during embryogenesis. By
sequence similarity, the beta3GalT genes fall into at least two
groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3,
beta3GalT5). This gene encodes the most probable candidate for
synthesis of the type 1 Lewis antigens which are frequently found
to be elevated in gastrointestinal and pancreatic cancers. The
encoded protein is inactive with N-linked glycoproteins and
functions in mucin glycosylation. Five transcript variants have
been described which differ in the 5' UTR. All transcript variants
encode an identical protein.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This B3GALT5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-84 amino acids from the N-terminal region of human B3GALT5.

Beta-1, 3-galactosyltransferase 5

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.