COL1A2 Antibody

Primary Antibodies

Blue Ice

129 kDa

This gene encodes the pro-alpha2 chain of type I collagen
whose triple helix comprises two alpha1 chains and one alpha2
chain. Type I is a fibril-forming collagen found in most connective
tissues and is abundant in bone, cornea, dermis and tendon.
Mutations in this gene are associated with osteogenesis imperfecta
types I-IV, Ehlers-Danlos syndrome type VIIB, recessive
Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and
atypical Marfan syndrome. Symptoms associated with mutations in
this gene, however, tend to be less severe than mutations in the
gene for the alpha1 chain of type I collagen (COL1A1) reflecting
the different role of alpha2 chains in matrix integrity. Three
transcripts, resulting from the use of alternate polyadenylation
signals, have been identified for this gene. [provided by R.
Dalgleish].

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This COL1A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-43 amino acids from the N-terminal region of human COL1A2.

Collagen alpha-2(I) chain

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.