HRAS Antibody

Primary Antibodies

Blue Ice

21 kDa

This gene belongs to the Ras oncogene family, whose
members are related to the transforming genes of mammalian sarcoma
retroviruses. The products encoded by these genes function in
signal transduction pathways. These proteins can bind GTP and GDP,
and they have intrinsic GTPase activity. This protein undergoes a
continuous cycle of de- and re-palmitoylation, which regulates its
rapid exchange between the plasma membrane and the Golgi apparatus.
Mutations in this gene cause Costello syndrome, a disease
characterized by increased growth at the prenatal stage, growth
deficiency at the postnatal stage, predisposition to tumor
formation, mental retardation, skin and musculoskeletal
abnormalities, distinctive facial appearance and cardiovascular
abnormalities. Defects in this gene are implicated in a variety of
cancers, including bladder cancer, follicular thyroid cancer, and
oral squamous cell carcinoma. Multiple transcript variants, which
encode different isoforms, have been identified for this gene.

None

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Supplied in PBS with 0.09% (W/V) sodium azide.

Predicted species reactivity based on immunogen sequence: Chicken, Rat

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.