PIK3C2A Antibody

For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:10~50

blue ice or room temperature

191 kDa

The protein encoded by this gene belongs to thephosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles insignaling pathways involved in cell proliferation, oncogenictransformation, cell survival, cell migration, and intracellularprotein trafficking. This protein contains a lipid kinase catalyticdomain as well as a C-terminal C2 domain, a characteristic of classII PI3-kinases. C2 domains act as calcium-dependent phospholipidbinding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinaseactivity of this protein is not sensitive to nanomolar levels ofthe inhibitor wortmanin. This protein was shown to be able to beactivated by insulin and may be involved in integrin-dependentsignaling.

Batch dependent

This PIK3C2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1431-1458 amino acids from the C-terminal region of human PIK3C2A.

Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.