TGIF1 Antibody

For WB starting dilution is: 1:1000

blue ice or room temperature

43 kDa

The protein encoded by this gene is a member of thethree-amino acid loop extension (TALE) superclass of atypicalhomeodomains. TALE homeobox proteins are highly conservedtranscription regulators. This particular homeodomain binds to apreviously characterized retinoid X receptor responsive elementfrom the cellular retinol-binding protein II promoter. In additionto its role in inhibiting 9-cis-retinoic acid-dependent RXR alphatranscription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 andmay participate in the transmission of nuclear signals duringdevelopment and in the adult. Mutations in this gene are associatedwith holoprosencephaly type 4, which is a structural anomaly of thebrain. Alternative splicing has been observed at this locus andeight variants, encoding four distinct isoforms, are described.

This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Supplied in PBS with 0.09% (W/V) sodium azide.

This TGIF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human TGIF1.

Homeobox protein TGIF1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.