HLA-DQA1 Antibody

Primary Antibodies

Blue Ice

28 kDa

HLA-DQA1 belongs to the HLA class II alpha chain
paralogues. The class II molecule is a heterodimer consisting of an
alpha (DQA) and a beta chain (DQB), both anchored in the membrane.
It plays a central role in the immune system by presenting peptides
derived from extracellular proteins. Class II molecules are
expressed in antigen presenting cells (APC: B Lymphocytes,
dendritic cells, macrophages). The alpha chain is approximately
33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader
peptide, exons 2 and 3 encode the two extracellular domains, and
exon 4 encodes the transmembrane domain and the cytoplasmic tail.
Within the DQ molecule both the alpha chain and the beta chain
contain the polymorphisms specifying the peptide binding
specificities, resulting in up to four different molecules. Typing
for these polymorphisms is routinely done for bone marrow
transplantation.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This HLA-DQA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the N-terminal region of human HLA-DQA1.

HLA class II histocompatibility antigen, DQ alpha 1 chain

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.