GREM1 Antibody

Primary Antibodies

Blue Ice

21 kDa

This gene encodes a member of the BMP (bone morphogenic
protein) antagonist family. Like BMPs, BMP antagonists contain
cystine knots and typically form homo- and heterodimers. The CAN
(cerberus and dan) subfamily of BMP antagonists, to which this gene
belongs, is characterized by a C-terminal cystine knot with an
eight-membered ring. The antagonistic effect of the secreted
glycosylated protein encoded by this gene is likely due to its
direct binding to BMP proteins. As an antagonist of BMP, this gene
may play a role in regulating organogenesis, body patterning, and
tissue differentiation. In mouse, this protein has been shown to
relay the sonic hedgehog (SHH) signal from the polarizing region to
the apical ectodermal ridge during limb bud outgrowth.
Alternatively spliced transcript variants encoding different
isoforms have been found for this gene.

None

batch dependent

For WB starting dilution is: 1:1000

This GREM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the C-terminal region of human GREM1.

Gremlin-1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.