MRPS12 Antibody

Rabbit Ig

Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Mammalian mitochondrial ribosomal proteins are encoded bynuclear genes and help in protein synthesis within themitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of asmall 28S subunit and a large 39S subunit. They have an estimated75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalianmitoribosomes and prokaryotic ribosomes is that the latter containa 5S rRNA. Among different species, the proteins comprising themitoribosome differ greatly in sequence, and sometimes inbiochemical properties, which prevents easy recognition by sequencehomology. This gene encodes a 28S subunit protein that belongs tothe ribosomal protein S12P family. The encoded protein is a keycomponent of the ribosomal small subunit and controls the decodingfidelity and susceptibility to aminoglycoside antibiotics. The genefor mitochondrial seryl-tRNA synthetase is located upstream andadjacent to this gene, and both genes are possible candidates forthe autosomal dominant deafness gene (DFNA4). Splice variants thatdiffer in the 5' UTR have been found for this gene; all threevariants encode the same protein.

Batch dependent

This MRPS12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-59 amino acids from the Central region of human MRPS12.

28S ribosomal protein S12, mitochondrial

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.