ASPH Antibody

Primary Antibodies

Blue Ice

86 kDa

This gene is thought to play an important role in calcium
homeostasis. The gene is expressed from two promoters and undergoes
extensive alternative splicing. The encoded set of proteins share
varying amounts of overlap near their N-termini but have
substantial variations in their C-terminal domains resulting in
distinct functional properties. The longest isoforms (a and f)
include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain
that hydroxylates aspartic acid or asparagine residues in the
epidermal growth factor (EGF)-like domains of some proteins,
including protein C, coagulation factors VII, IX, and X, and the
complement factors C1R and C1S. Other isoforms differ primarily in
the C-terminal sequence and lack the hydroxylase domain, and some
have been localized to the endoplasmic and sarcoplasmic reticulum.
Some of these isoforms are found in complexes with calsequestrin,
triadin, and the ryanodine receptor, and have been shown to
regulate calcium release from the sarcoplasmic reticulum. Some
isoforms have been implicated in metastasis.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This ASPH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 294-323 amino acids from the Central region of human ASPH.

Aspartyl/asparaginyl beta-hydroxylase

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.