RASA1 Antibody

Primary Antibodies

Blue Ice

116 kDa

The protein encoded by this gene is located in the
cytoplasm and is part of the GAP1 family of GTPase-activating
proteins. The gene product stimulates the GTPase activity of normal
RAS p21 but not its oncogenic counterpart. Acting as a suppressor
of RAS function, the protein enhances the weak intrinsic GTPase
activity of RAS proteins resulting in the inactive GDP-bound form
of RAS, thereby allowing control of cellular proliferation and
differentiation. Mutations leading to changes in the binding sites
of either protein are associated with basal cell carcinomas.
Alternative splicing results in two isoforms where the shorter
isoform, lacking the N-terminal hydrophobic region but retaining
the same activity, appears to be abundantly expressed in placental
but not adult tissues.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

Predicted species reactivity based on immunogen sequence: Rat

Polyclonal

Homo sapiens

Optimal dilutions for each application to be determined by the researcher.