ITM2B Antibody

For IHC-P starting dilution is: 1:10~50

For WB starting dilution is: 1:1000

blue ice or room temperature

30 kDa

Amyloid precursor proteins are processed by beta-secretaseand gamma-secretase to produce beta-amyloid peptides which form thecharacteristic plaques of Alzheimer disease. This gene encodes atransmembrane protein which is processed at the C-terminus by furinor furin-like proteases to produce a small secreted peptide whichinhibits the deposition of beta-amyloid. Mutations which result inextension of the C-terminal end of the encoded protein, therebyincreasing the size of the secreted peptide, are associated withtwo neurogenerative diseases, familial British dementia andfamilial Danish dementia.

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This ITM2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-247 amino acids from the C-terminal region of human ITM2B.

Integral membrane protein 2B

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.