SFTPC Antibody

Primary Antibodies

Blue Ice

21 kDa

This gene encodes the pulmonary-associated surfactant
protein C (SPC), an extremely hydrophobic surfactant protein
essential for lung function and homeostasis after birth. Pulmonary
surfactant is a surface-active lipoprotein complex composed of 90%
lipids and 10% proteins which include plasma proteins and
apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted
by the alveolar cells of the lung and maintains the stability of
pulmonary tissue by reducing the surface tension of fluids that
coat the lung. Multiple mutations in this gene have been
identified, which cause pulmonary surfactant metabolism dysfunction
type 2, also called pulmonary alveolar proteinosis due to
surfactant protein C deficiency, and are associated with
interstitial lung disease in older infants, children, and adults.
Alternatively spliced transcript variants encoding different
protein isoforms have been identified.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This SFTPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the C-terminal region of human SFTPC.

Pulmonary surfactant-associated protein C

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.