RANGAP1 Antibody

Primary Antibodies

Blue Ice

64 kDa

RanGAP1, is a homodimeric 65-kD polypeptide that
specifically induces the GTPase activity of RAN, but not of RAS by
over 1, 000-fold. RanGAP1 is the immediate antagonist of RCC1, a
regulator molecule that keeps RAN in the active, GTP-bound state.
The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence
is unrelated to that of GTPase activators for other RAS-related
proteins, but is 88% identical to Fug1, the murine homolog of yeast
Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the
nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN
GTP/GDP cycle.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This RANGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human RANGAP1.

Ran GTPase-activating protein 1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.