HLA-DPB1 Antibody

Primary Antibodies

Blue Ice

29 kDa

HLA-DPB belongs to the HLA class II beta chain paralogues.
This class II molecule is a heterodimer consisting of an alpha
(DPA) and a beta chain (DPB), both anchored in the membrane. It
plays a central role in the immune system by presenting peptides
derived from extracellular proteins. Class II molecules are
expressed in antigen presenting cells (APC: B lymphocytes,
dendritic cells, macrophages). The beta chain is approximately
26-28 kDa and its gene contains 6 exons. Exon one encodes the
leader peptide, exons 2 and 3 encode the two extracellular domains,
exon 4 encodes the transmembrane domain and exon 5 encodes the
cytoplasmic tail. Within the DP molecule both the alpha chain and
the beta chain contain the polymorphisms specifying the peptide
binding specificities, resulting in up to 4 different molecules.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This HLA-DPB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-105 amino acids from the Central region of human HLA-DPB1.

HLA class II histocompatibility antigen, DP beta 1 chain

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.