TRAF1 Antibody

Primary Antibodies

Blue Ice

46 kDa

The protein encoded by this gene is a member of the TNF
receptor (TNFR) associated factor (TRAF) protein family. TRAF
proteins associate with, and mediate the signal transduction from
various receptors of the TNFR superfamily. This protein and TRAF2
form a heterodimeric complex, which is required for
TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The
protein complex formed by this protein and TRAF2 also interacts
with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the
anti-apoptotic signals from TNF receptors. The expression of this
protein can be induced by Epstein-Barr virus (EBV). EBV infection
membrane protein 1 (LMP1) is found to interact with this and other
TRAF proteins; this interaction is thought to link LMP1-mediated B
lymphocyte transformation to the signal transduction from TNFR
family receptors. Three transcript variants encoding two different
isoforms have been found for this gene.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This TRAF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human TRAF1.

TNF receptor-associated factor 1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.