UGT1A1 Antibody

Primary Antibodies

Blue Ice

60 kDa

This gene encodes a UDP-glucuronosyltransferase, an enzyme
of the glucuronidation pathway that transforms small lipophilic
molecules, such as steroids, bilirubin, hormones, and drugs, into
water-soluble, excretable metabolites. This gene is part of a
complex locus that encodes several UDP-glucuronosyltransferases.
The locus includes thirteen unique alternate first exons followed
by four common exons. Four of the alternate first exons are
considered pseudogenes. Each of the remaining nine 5' exons may be
spliced to the four common exons, resulting in nine proteins with
different N-termini and identical C-termini. Each first exon
encodes the substrate binding site, and is regulated by its own
promoter. The preferred substrate of this enzyme is bilirubin,
although it also has moderate activity with simple phenols,
flavones, and C18 steroids. Mutations in this gene result in
Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

None

This antibody is purified through a protein A column, followed by peptide affinity purification.

Supplied in PBS with 0.09% (W/V) sodium azide.

This UGT1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-90 amino acids from the N-terminal region of human UGT1A1.

UDP-glucuronosyltransferase 1-1

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.