Hersteller |
ProSci
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human |
Format |
Liquid |
Applikationen |
WB, IHC-P |
Menge |
400 ul |
Host |
Rabbit |
ArtNr |
PRS-57-532-400ul |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Shipping |
blue ice or RT |
By Research Area |
Immunology, Signal Transduction |
Immunogen |
This PPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1301-1330 amino acids from the C-terminal region of human PPL. |
Applications |
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50 |
Predicted Molecular Weight |
205 kDa |
Purification |
This antibody is purified through a protein A column, followed by peptide affinity purification. |
Clonality |
Polyclonal |
Isotype |
Rabbit Ig |
Conjugate |
Unconjugated |
Buffer |
Supplied in PBS with 0.09% (W/V) sodium azide. |
Concentration |
batch dependent |
Storage Conditions |
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
Disclaimer |
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only. |
Modifications |
None |
Ncbi Official Symbol |
PPL |
Accession # |
O60437 |
Ncbi Gene Id # |
5493 |
User Note |
Optimal dilutions for each application to be determined by the researcher. |
Ncbi Official Symbol |
PPL |
Ncbi Official Full Name |
Periplakin |
Ncbi Organism |
Homo sapiens |
Swissprot # |
O60437 |
Background |
The protein encoded by this gene is a component ofdesmosomes and of the epidermal cornified envelope inkeratinocytes. The N-terminal domain of this protein interacts withthe plasma membrane and its C-terminus interacts with intermediatefilaments. Through its rod domain, this protein forms complexeswith envoplakin. This protein may serve as a link between thecornified envelope and desmosomes as well as intermediatefilaments. AKT1/PKB, a protein kinase mediating a variety of cellgrowth and survival signaling processes, is reported to interactwith this protein, suggesting a possible role for this protein as alocalization signal in AKT1-mediated signaling. [provided byRefSeq]. |
Background References 1 |
Pinheiro, A.P., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) : |
Background References 2 |
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) : |
Background References 3 |
Pyle, A.L., et al. Cardiovasc. Pathol. 19 (2), E13-E20 (2010) : |
Background References 4 |
Huang, Y., et al. Arch. Dermatol. Res. 301(10):703-709(2009) |
1st Image Caption |
Western blot analysis in T47D cell line lysates (35ug/lane). |
2nd Image Caption |
PPL Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human skin tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. |
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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.