ARNT Antibody

For IF starting dilution is: 1:10~50

For WB starting dilution is: 1:1000

blue ice or room temperature

87 kDa

The aryl hydrocarbon (Ah) receptor is involved in theinduction of several enzymes that participate in xenobioticmetabolism. The ligand-free, cytosolic form of the Ah receptor iscomplexed to heat shock protein 90. Binding of ligand, whichincludes dioxin and polycyclic aromatic hydrocarbons, results intranslocation of the ligand-binding subunit only to the nucleus.Induction of enzymes involved in xenobiotic metabolism occursthrough binding of the ligand-bound Ah receptor to xenobioticresponsive elements in the promoters of genes for these enzymes.This gene encodes a protein that forms a complex with theligand-bound Ah receptor, and is required for receptor function.The encoded protein has also been identified as the beta subunit ofa heterodimeric transcription factor, hypoxia-inducible factor 1. At(1; 12)(q21; p13) translocation, which results in a TEL-ARNT fusionprotein, is associated with acute myeloblastic leukemia.Alternative splicing results in multiple transcript variants.

This antibody is purified through a protein G column, followed by dialysis against PBS.

Supplied in PBS with 0.09% (W/V) sodium azide.

This ARNT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 513-544 amino acids from the Central region of human ARNT.

Aryl hydrocarbon receptor nuclear translocator

Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.